Aug 01

Be Human Stop Child Abuse : Vol 25, 31st July, 2013

Paternal age and fertility

  1. Maternal age plays a major role in determining a woman’s fertility, regardless of the means used to achieve pregnancy (except donor egg)
  2. Women under 30 years old have higher pregnancy rates at three, six and 12 months than women over 30 years old.
  3. Women are generally aware of the reproductive issues related to advanced maternal age, typically defined as 35 years of age or older on the estimated date of confinement. These issues include higher risks of infertility, fetal aneuploidy, gestational diabetes, preeclampsia, and stillbirth
  4. Both women and men should be aware that childbearing after age 40 years is associated with higher rates of subfertility and adverse pregnancy related outcomes.
  5. Bulk of data point to a decrease in fertility with increasing age. This may be due to a number of factors, including decreased coital frequency, reduced sexual functioning, and poorer semen quality as men age.
  6. Advanced paternal age appears to be associated with a modest increase in the risk of miscarriage; this risk is lower than that observed with advanced maternal age.
  7. Older men can be reassured that any excess risk of disease in their offspring related to paternal age is very small, but not zero. Advanced paternal age is associated with an increase in new autosomal dominant mutations. The best estimate of risk of autosomal dominant disease in progeny is ≤0.5 percent.
  8. Infants born to older fathers have slightly increased risk of birth defects; however, the association is weak, thus paternal age likely plays no more than a small role in the etiology of birth defects.
  9. Paternal age appears to be a significant predictor of schizophrenia, but not of other psychiatric disorders, in offspring.
  10. There may be a small, but statistically significant, association between advancing paternal age and risk of autism spectrum disorders.
  11. Spontaneous germline mutations in X-linked genes may be more common with advancing paternal age. These mutations would be transmitted from carrier daughters to affected grandsons.
  12. There does not appear to be a significantly increased risk of fetal autosomal or sex chromosome aneuploidy related to advanced paternal age.
  13. Germ line cell mutations have been associated with aging and may be a cause of childhood cancer among children of older parents.





Dr Vinay Aggarwal, President, Elect CMAAO

Dr K Vijayakumar (National President) IMA

Dr N Saini (Secretary General) IMA

Dr M Pillai (Chairman Organising Committee)

Dr D R Rai (Organising Secretary)

Dr S Arulrhaj (Chairman Scientific Committee)

Dr KK Aggarwal (Co-Chairman & Editor)

  1. Dear Sir, Nice updates. Regards:Dr Kanta

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